1 / 1
|
DeCS
|
|
|
Descriptor English:
|
|
Anaphase-Promoting Complex-Cyclosome
|
Descriptor Spanish:
|
|
Ciclosoma-Complejo Promotor de la Anafase
|
Descriptor Portuguese:
|
|
Ciclossomo-Complexo Promotor de Anáfase
|
Synonyms English:
|
|
Anaphase Promoting Complex
|
Tree Number:
|
|
D08.811.464.938.750.092
D12.776.167.024
|
Definition English:
|
|
An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability. |
History Note English:
|
|
2014
|
Allowable Qualifiers English:
|
|
|
Record Number:
|
|
55272
|
Unique Identifier:
|
|
D064173
|
Occurrence in VHL:
|
|
|
Similar:
|
|
DeCS CID-10 SciELO LILACS LIS
|